Qualys vs SentinelOne: Complete Comparison (2026)
Choosing between Qualys and SentinelOne is a common decision for cybersecurity buyers in 2026. Qualys has been in the market since 1999, giving it a 14-year head start over SentinelOne (founded 2013). Qualys serves 10K+ orgs users while SentinelOne has 12K+ orgs users globally. Qualys differentiates with vulnerability scanning and compliance monitoring, while SentinelOne leads with ai-powered endpoint protection and autonomous response. In this head-to-head comparison, SentinelOne earns a higher hiltonsoftware.co score of 94/100 — but the right choice depends on your specific needs, budget, and team size.
Quick Comparison
Feature-by-Feature Comparison
Pros & Cons at a Glance
After comparing Qualys and SentinelOne across features, pricing, and user satisfaction, SentinelOne takes the lead with a score of 94/100 versus Qualys's 86/100. SentinelOne's key advantages include "autonomous threat response" and "excellent edr capabilities". That said, Qualys has its own strengths — particularly "comprehensive vulnerability management" — making it a viable alternative for specific use cases.
Neither Qualys nor SentinelOne offers a free plan. Qualys starts at Custom pricing and SentinelOne at $45/endpoint/yr. For the investment, Qualys delivers vulnerability scanning and compliance monitoring, while SentinelOne provides ai-powered endpoint protection and autonomous response.
Bottom line: Choose Qualys if you need enterprise security teams needing comprehensive vulnerability and compliance scanning. Go with SentinelOne if your priority is enterprises wanting ai-driven autonomous endpoint protection and response. Both are strong cybersecurity tools — we recommend trying a trial of each before committing.
Enterprise security teams needing comprehensive vulnerability and compliance scanning.
Enterprises wanting AI-driven autonomous endpoint protection and response.